Emeric Le Floc'h (IfA) Title: Luminous starbursts and active nuclei at high redshift: a mid-infrared perspective Abstract: Although they are rare objects in the present day Universe, Luminous Infrared (IR) Galaxies played a significant role in the evolution of structures at high redshift. I will present a number of key results obtained in the mid-IR with the Spitzer Space Telescope and that revolutionized our understanding of the contribution of luminous galaxies to the star formation history and the growth of supermassive black holes. In particular I will discuss their nature and their relationship within other populations of distant sources using a multi-wavelength characterization of their spectral properties, luminosity function, morphology and clustering. I will emphasize the large contribution of IR-luminous "composite" galaxies experiencing both star formation and nuclear accretion, which will finally lead me to underline the difficulties of interpreting IR surveys when starbursts and AGNs are not carefully distinguished. Avoiding these limitations, an independent approach for probing massive star formation based on cosmic GRBs will be presented. I will show that Spitzer revealed a weak overlap between GRB-selected star-forming galaxies and luminous dusty starbursts. Possible scenarios will be described to explain this result.